Synthesis, spectral characterization, antimicrobial activity and docking studies against DNA Gyrase-A of new 4-chloro-3-nitrobenzene sulfonamide derivatives

doi:10.25135/acg.oc.90.20.11.1858

Paper

Synthesis, spectral characterization, antimicrobial activity and docking studies against DNA Gyrase-A of new 4-chloro-3-nitrobenzene sulfonamide derivatives

Published Dec 26, 2020 · K. Kumar, R. M. N. Kalla, M. Varalakshmi

UNKNOWN SJR score

4

Citations

1

Influential Citations

Open Access PDF Full text Semantic Scholar

Abstract

A series of new 4-chloro-3-nitrobenzene sulfonamide derivatives 3(a-j) were synthesized from 4-chloro-3-nitrobenzene sulfonyl chloride by reacting various amino acid esters and amines 2(a-j) in high yields. The structures of all the synthesized compounds were characterized by the IR, NMR (1H & 13C), mass and elemental analyses. Further, all the synthesized compounds were tested for the antimicrobial activity and docking studies were carried out with DNA Gyrase-A. Most of the compounds showed good to moderate antimicrobial activities and binding affinity towards DNA Gyrase-A structure.

Study Snapshot

New 4-chloro-3-nitrobenzene sulfonamide derivatives show good to moderate antimicrobial activity and binding affinity towards DNA Gyrase-A, offering potential as new antimicrobial agents.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Synthesis, spectral characterization, antimicrobial activity and docking studies against DNA Gyrase-A of new 4-chloro-3-nitrobenzene sulfonamide derivatives

Sign up to use Study Snapshot

References

Citations

Synthesis, DFT investigations, antibacterial activity, and SAR-study of novel thiophene-coumarin hybrids

Novel thiophene-coumarin hybrids show diverse antibacterial activity against various bacteria and fungi, with hybrid 9a showing the highest potency in inhibiting DNA gyrase.

N-alkylbenzimidazole silver(I) complexes: Synthesis, biological evaluation and molecular docking study

N-alkylbenzimidazole silver(I) complexes show higher antimicrobial activity against bacteria than fungi, with complex 2e showing remarkable activity against Candida albicans and Candida glabrata.

Synthesis and Study Biological Activities of Sulfur - Containing Drugs

Sulfur-containing drugs have significant medical uses as antibacterial, antifungal, and anticancer agents, with various methods for preparing organic sulfur compounds.

Novel naphthalene-1,5-diamine containing urea/thiourea derivatives – Promising antimicrobial agents

Novel urea/thiourea derivatives of naphthalene-1,5-diamine show promising antimicrobial activity against grampositive and gram-negative bacteria and fungi, making them promising drug candidates for further studies.