Synthesis, Characterization and Biological Evaluation of 4-(4-Bromo-1-Hydroxy Naphthalen-2-Yl)-6-(4-Methoxy Phenyl)-5,6-Dihydropyrimidine-2(1h)-One

doi:10.48175/ijarsct-2446

Paper

Synthesis, Characterization and Biological Evaluation of 4-(4-Bromo-1-Hydroxy Naphthalen-2-Yl)-6-(4-Methoxy Phenyl)-5,6-Dihydropyrimidine-2(1h)-One

Published Dec 31, 2021 · V. M. Sherekar, K. P. Kakade, N. S. Padole

International Journal of Advanced Research in Science, Communication and Technology

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Abstract

1-(4- Bromo -1-hydroxynaphthalen-2-yl)-ethan-1-one was prepared by refluxing 4- bromonaphthalen-1-ol with glacial acetic acid in presence of fused ZnCl2. By condensing 1-(4- bromo -1-hydroxynaphthalen-2- yl)-ethan-1-ones with 4- methoxy benzaldehyde, to prepared by 1-(4- bromo -1- hydroxynaphthalen-2-yl)-3-(4-methoxy phenyl)-prop-2-en-1-one were synthesized.1-(4- bromo -1- hydroxynaphthalen-2-yl)-3-(4-methoxy phenyl)-prop-2-en-1-one, urea and concentrated HCl in DMF were added and refluxed. Cool and pour in crushed ice. Treat it with cold NH4OH solution to obtain titled compounds. The compounds thus synthesized have been characterized by physical and spectral data. All of these titled synthesized compounds have been screened for antimicrobial study and are found to possess excellent antimicrobial activities.

Study Snapshot

4-(4-Bromo-1-Hydroxy Naphthalen-2-Yl)-6-(4-Methoxy Phenyl)-5,6-Dihydropyrimidine-2(1h)-One exhibits excellent antimicrobial activities.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis, Characterization and Biological Evaluation of 4-(4-Bromo-1-Hydroxy Naphthalen-2-Yl)-6-(4-Methoxy Phenyl)-5,6-Dihydropyrimidine-2(1h)-One

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