Synthesis, characterization and pharmacological evaluation of cinnoline (thiophene) derivatives

Paper

Synthesis, characterization and pharmacological evaluation of cinnoline (thiophene) derivatives

Published Dec 1, 2015 · M. Pankaj, S. Vikas, K. Minu

The Pharma Innovation Journal

UNKNOWN SJR score

3

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0

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Abstract

The review of literature showed that cinnoline derivatives were found to elicit many pharmacological actions like anti-hypertensive, antithrombotic, antihistamine, antileukemic, CNS activity, anti tumor, antibacterial and antisecretory activity.In the substituted Cinnoline thiophene series, the compounds which are halogen mainly Chloro, Bromo and Fluoro Substituted were showed potent antibacterial, anti-inflammatory and anti-fungal activity than other compounds. Especially Chloro Substituted Compounds Showed more potent antimicrobial activity and anti-inflammatory activity among all the substituted cinnoline thiophene compounds.

Literature Review

Study Snapshot

Cinnoline derivatives show various pharmacological actions, with chloro, bromo, and fluoro substituted compounds showing potent antibacterial, anti-inflammatory, and antifungal activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis, characterization and pharmacological evaluation of cinnoline (thiophene) derivatives

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