Three-component synthesis and characterization of 2-amino-4-(4methoxyphenyl)-6-(piperidin-1-yl)-3,5-dicarbonitrile pyridine

Paper

Three-component synthesis and characterization of 2-amino-4-(4methoxyphenyl)-6-(piperidin-1-yl)-3,5-dicarbonitrile pyridine

Published 2011 · Wu Feng

Journal of Chongqing University

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Abstract

Novel 2-amino-4-(4-methoxyphenyl)-6-(piperidin-1-yl)pyridine-3,5-dicarbonitrile is synthesized using malononitrile,4-methoxybenzaldehyde and piperidine as starting material in methanol by one-spot.The yield is 40% with three-component reaction at room temperature.The structure is confirmed by 1H NMR,MS and X-ray single crystal diffraction.

Study Snapshot

The novel 2-amino-4-(4-methoxyphenyl)-6-(piperidin-1-yl)-3,5-dicarbonitrile pyridine is synthesized with a 40% yield using malononitrile,4-methoxybenzaldehyde, and

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Three-component synthesis and characterization of 2-amino-4-(4methoxyphenyl)-6-(piperidin-1-yl)-3,5-dicarbonitrile pyridine

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