Synthesis and Characterization of 2-Bromo-4,5,2′,4′,6′-Pentamethoxyl Benzophenone

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Synthesis and Characterization of 2-Bromo-4,5,2′,4′,6′-Pentamethoxyl Benzophenone

Published 2011 · W. Jin

Yunnan Chemical Technology

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Abstract

2-Bromo-4,5,2′,4′,6′-pentamethoxyl benzophenone,the key intermediate for preparing norathyriol was synthesized from trimethoxybenzene through two steps.Firstly,trimethoxybenzene was prepared from m-trihydroxybenzene by a methylation reaction under Me2CO3/K2CO3/DMSO system at 120~150 ℃ in 95% yield.Secondly,the title compound was prepared from trimethoxybenzene via Friedel-Crafts reaction with 2-bromo-4,5-dimethoxy benzoic acid utilizing POCl3 in 1,2-dichloroethane at 70~80℃in 85% yield.The title compound is firenew,its structure was confirmed by IR,UV,EIMS,13CNMR and 1HNMR.

Study Snapshot

This study successfully synthesized 2-Bromo-4,5,2′,4′,6′-pentamethoxyl benzophenone, a key intermediate for preparing norathyriol, from trimethoxybenzene in 85% yield.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis and Characterization of 2-Bromo-4,5,2′,4′,6′-Pentamethoxyl Benzophenone

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