Synthesis and characterization of (3-Chlorophenyl)(1-(5-phenyl-1,3,4-oxadiazol-2-yl)indolizin-3-yl)methanone derivatives as anticancer and antimicrobial agents

doi:10.1016/J.CDC.2021.100691

Paper

Synthesis and characterization of (3-Chlorophenyl)(1-(5-phenyl-1,3,4-oxadiazol-2-yl)indolizin-3-yl)methanone derivatives as anticancer and antimicrobial agents

Published Mar 23, 2021 · G Mahanthesha, T. Suresh, Y. Bodke

Chemical Data Collections

Q3 SJR score

2

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

The novel series of 3-Chlorophenyl (1-(5-phenyl-1,3,4-oxadiazol-2-yl) indolizin-3-yl) methanone derivatives show potent anticancer, antibacterial, and antifungal activity against MCF-7 breast carcinoma cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Synthesis and characterization of (3-Chlorophenyl)(1-(5-phenyl-1,3,4-oxadiazol-2-yl)indolizin-3-yl)methanone derivatives as anticancer and antimicrobial agents

Sign up to use Study Snapshot

References

Inhibitory activities of indolizine derivatives: a patent review

Indolizine-based compounds show potential in anticancer, anti-tubercular, anti-inflammatory, and enzymatic inhibitory activities, offering a major breakthrough in pharmaceutical research.

Water Soluble NIR Absorbing and Emitting Indolizine Cyanine and Indolizine Squaraine Dyes for Biological Imaging.

Indolizine cyanine and squaraine dyes with water-soluble sulfonate groups show potential for non-invasive, high-resolution, and rapid biological imaging.

Qualitative anti-tubercular activity of synthetic ethyl 7-acetyl2-substituted-3-(4-substituted benzoyl) indolizine-1-carboxylate analogues

Synthetic ethyl 7-acetyl2-substituted-3-(4-substituted benzoyl) indolizine-1-carboxylate analogues show promising anti-tubercular activity.

A mini review on biological potential of 1,3,4-oxadiazole derivatives

1,3,4-oxadiazole derivatives show broad biological activity, including antibacterial, antifungal, analgesic, anti-inflammatory, antiviral, anticancer, antidepressant, and anticonvulsant properties.

Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole

Derivatives of 1,3,4-oxadiazole show promising anti-cancer activity, potentially surpassing reference drugs and becoming main new anti-cancer drugs in the future.

Molecular modeling studies and anti-TB activity of trisubstituted indolizine analogues; molecular docking and dynamic inputs

Trisubstituted indolizine analogues show potential anti-TB activity against susceptible and multidrug-resistant strains of Mycobacterium tuberculosis, with potential for further anti-TB drug discovery.

Greener synthesis of indolizine analogues using water as a base and solvent: study for larvicidal activity against Anopheles arabiensis

Greener synthesis of indolizine analogues using water as a base and solvent, yields promising larvicidal agents against Anopheles arabiensis.

The changing 50% inhibitory concentration (IC50) of cisplatin: a pilot study on the artifacts of the MTT assay and the precise measurement of density-dependent chemoresistance in ovarian cancer

The limiting dilution assay accurately measures density-dependent chemoresistance in ovarian cancer, overcoming MTT artifacts and providing valuable insights for both basic and clinical cancer research.

New indolizines with phenanthroline skeleton: Synthesis, structure, antimycobacterial and anticancer evaluation.

Two new classes of indolizine with phenanthroline skeleton show significant antitumor growth inhibitory activity against breast cancer, suggesting potential DNA interaction.

Citations