SYNTHESIS AND CHARACTERIZATION OF (R)-2-{[5-BROMO-1-(3-BROMOPROPYL)-1H(SUBSTITUTED)-INDOL-3-YL]METHYL} PYRROLIDINE-1-CARBOXYLIC ACID DERIVATIVES VIA JAPP-KLINGEMANN AND FISCHER INDOLE CYCLIZATION REACTIONS

doi:10.7897/2230-8407.09231

Paper

SYNTHESIS AND CHARACTERIZATION OF (R)-2-{[5-BROMO-1-(3-BROMOPROPYL)-1H(SUBSTITUTED)-INDOL-3-YL]METHYL} PYRROLIDINE-1-CARBOXYLIC ACID DERIVATIVES VIA JAPP-KLINGEMANN AND FISCHER INDOLE CYCLIZATION REACTIONS

Published Mar 29, 2018 · Nadimenti Mogulaiah, P. Sundar, Tasleem

International research journal of pharmacy

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Abstract

A series of novel (R)-2-{[5-bromo-1-(3-bromopropyl)-1H (substituted)-indol-3-yl]methyl}pyrrolidine-1-carboxylic acid (T1-T5) derivates were synthesized by electrophilic substitution at 1st position of (R)-2-{[5-bromo-1-(3-bromopropyl)-1H-indol-3-yl]methyl}pyrrolidine-1-carboxylic acid with various halides. The starting material (R)-2-{[5-bromo-1-(3-bromopropyl)-1H-indol-3-yl]methyl}pyrrolidine-1-carboxylic acid was synthesized from 4-bromo aniline by japp-klingemann and fischer indole cyclization reactions. The synthesized compounds were characterized by IR, 1H NMR MASS spectroscopy.

Study Snapshot

The study synthesized novel (R)-2-[5-bromo-1-(3-bromopropyl)-1H (substituted)-indol-3-yl]methyl-pyrrolidine-1-carboxylic acid derivates by electrophilic substitution at

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

SYNTHESIS AND CHARACTERIZATION OF (R)-2-{[5-BROMO-1-(3-BROMOPROPYL)-1H(SUBSTITUTED)-INDOL-3-YL]METHYL} PYRROLIDINE-1-CARBOXYLIC ACID DERIVATIVES VIA JAPP-KLINGEMANN AND FISCHER INDOLE CYCLIZATION REACTIONS

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References

Citations

Dihydropyrimidines as Precursors for Synthesizing of Oxoketene gem-Dithiol and 1,2-Dithiol-3-Thione, a Facile Synthesis and Convenient Reaction Transformations

This study successfully synthesized oxoketen gem-dithols, ketenedithioacetal, and 1,2-dithiol-3-thione from indole and dihydropyrimidines, resulting in biological and pharmacologically active compounds.