Synthesis and characterization of a series of chiral alkoxymethyl morpholine analogs as dopamine receptor 4 (D4R) antagonists.

doi:10.1016/j.bmcl.2016.03.102

Paper

Synthesis and characterization of a series of chiral alkoxymethyl morpholine analogs as dopamine receptor 4 (D4R) antagonists.

Published May 15, 2016 · Jonathan O Witt, Andrea L. McCollum, Miguel A. Hurtado

Bioorganic & medicinal chemistry letters

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18

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Abstract

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Study Snapshot

Chiral alkoxymethyl morpholine analogs are potent and selective dopamine D4 receptor antagonists, with selectivity against other dopamine receptors.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis and characterization of a series of chiral alkoxymethyl morpholine analogs as dopamine receptor 4 (D4R) antagonists.

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