The synthesis of chromeno[2,3-b]indole from simple starting materials remains a demanding process. Herein, 2-bromoindole undergoes nucleophilic attack from salicylaldehyde, followed by intramolecular insertion of an aldehyde group and aromatization to generate the desired chromeno[2,3-b]indoles. Moreover, various functional groups were tolerated and a gram-scale synthesis of the product could be achieved under the optimized condition.

This study presents a practical synthesis of chromeno[2,3-b]indole from 2-bromoindole using an aldehyde group insertion/aromatization strategy, enabling gram-scale production with various functional groups tolerated.

Paper

Practical Synthesis of Chromeno[2,3-b]indole Skeleton via an Aldehyde Group Insertion/Aromatization Strategy.

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