Synthesis of Chromones from 1,1-Diacylcyclopropanes: Toward the Synthesis of Bromophycoic Acid E.

doi:10.1021/acs.joc.7b00648

Paper

Synthesis of Chromones from 1,1-Diacylcyclopropanes: Toward the Synthesis of Bromophycoic Acid E.

Published May 4, 2017 · Robert J. Smith, Duong Nhu, Mitchell R Clark

The Journal of organic chemistry

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21

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Abstract

A tandem deprotection-cyclization reaction of 1,1-diacylcyclopropanes is described which allows rapid access to structurally diverse 2,3-disubstituted chromones in good yields, and with straightforward purification. The utility of this reaction is showcased by the construction of the potent antibacterial marine natural product bromophycoic acid E scaffold.

Study Snapshot

This tandem deprotection-cyclization reaction allows rapid access to diverse 2,3-disubstituted chromones, potentially leading to the synthesis of bromophycoic acid E, a potent antibacterial marine natural product.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis of Chromones from 1,1-Diacylcyclopropanes: Toward the Synthesis of Bromophycoic Acid E.

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