Synthesis, crystal structure, and in vitro antiprotozoal activity of some 5-phenyl(methyl)sulfonyl-substituted dihydroisoxazoles

doi:10.1007/s00706-012-0866-6

Paper

Synthesis, crystal structure, and in vitro antiprotozoal activity of some 5-phenyl(methyl)sulfonyl-substituted dihydroisoxazoles

Published Jan 9, 2013 · Y. Dürüst, C. Altuğ, M. Kaiser

Monatshefte für Chemie - Chemical Monthly

UNKNOWN SJR score

4

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

Abstract4,5-Dihydroisoxazole derivatives are interesting synthetic targets that exhibit various biological activities, including anti-infective. Taking account of the principle of bioisosterism, a number of 4,5-dihydroisoxazoles carrying a phenyl- (or methyl-)sulfonyl group at position 5 were designed and synthesized by 1,3-dipolar cycloaddition of nitrolic acid-generated nitrile oxides with electron-deficient phenyl (or methyl) vinyl sulfones. The structures of all the cycloadducts were elucidated by means of spectroscopic methods (NMR, MS), X-ray diffraction, and physical characteristics. The in vitro antiprotozoal and cytotoxic activities of these heterocyclic compounds were investigated.Graphical abstract

Study Snapshot

5-phenyl(methyl)sulfonyl-substituted dihydroisoxazoles show in vitro antiprotozoal and cytotoxic activities, offering potential as anti-infective agents.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis, crystal structure, and in vitro antiprotozoal activity of some 5-phenyl(methyl)sulfonyl-substituted dihydroisoxazoles

References

Citations