Synthesis, Crystal Structure and Antitumor Activities of Ethyl (R)-2-(Biphenyl-4-carbonyl)-2,3,4,9-tetrahydro-1 H -pyrido[3,4-b]indole-1-carboxylate

doi:10.14102/J.CNKI.0254-5861.2011-1740

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Synthesis, Crystal Structure and Antitumor Activities of Ethyl (R)-2-(Biphenyl-4-carbonyl)-2,3,4,9-tetrahydro-1 H -pyrido[3,4-b]indole-1-carboxylate

Published Jan 10, 2018 · Ch Hu, D. Wei, Js Zhao

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Abstract

The title compound, ethyl (R)-2-(biphenyl-4-carbonyl)-2,3,4,9-tetrahydro-1H-pyri do-[3,4-b]indole-1-carboxylate (C27H24N2O3) has been synthesized, and its structure was charac-terized by H-1-NMR, C-13-NMR, ESI-MS and single-crystal X-ray diffraction. It crystallizes in the orthorhombic system, space group Pbca with a = 16.9950(8), b = 9.5445(4), c = 28.3188(3) angstrom, V = 4593.6(3) angstrom(3), Z = 8, T = 294.64(10) K, mu(MoK alpha) = 0.08 mm(-1), D-c = 1.228 g/cm(3), F(000) = 1792 and GOOF = 1.036. 11836 reflections were measured (7.04 2 sigma(I)) and wR = 0.1563 (all data). The preliminary biological tests show that the title compound has a good antitumor activity against Hela in vitro with the IC50 value of 4.71 mu mol/L.

Study Snapshot

Ethyl (R)-2-(biphenyl-4-carbonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate shows good antitumor activity against Hela in vitro with an

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Synthesis, Crystal Structure and Antitumor Activities of Ethyl (R)-2-(Biphenyl-4-carbonyl)-2,3,4,9-tetrahydro-1 H -pyrido[3,4-b]indole-1-carboxylate

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