Synthesis, Crystal Structure and Antitumour Activity of 3-Amino-N-(5-Fluoro-2-Methylphenyl)-4-Morpholino-1H-Indazole-1-Carboxamide

doi:10.3184/174751917X15065183733178

Paper

Synthesis, Crystal Structure and Antitumour Activity of 3-Amino-N-(5-Fluoro-2-Methylphenyl)-4-Morpholino-1H-Indazole-1-Carboxamide

Published Nov 1, 2017 · Xuechen Hao, Jiu-Fu Lu, Ye Chen

Journal of Chemical Research

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Abstract

Compound 3-amino-N-(5-fluoro-2-methylphenyl)-4-morpholino-1H-indazole-1-carboxamide has been synthesised by condensation of 4-fluoro-2-isocyanato-1-methylbenzene with 4-morpholino-1H-indazol-3-amine, which was prepared from 2,6-difluorobenzonitrile by amination with morpholine and then cyclisation with hydrazine hydrate. The crystal structure of the title compound was determined. In addition, the compound inhibits proliferation of some cancer cell lines.

Study Snapshot

3-amino-N-(5-fluoro-2-methylphenyl)-4-morpholino-1H-indazole-1-carboxamide inhibits cancer cell proliferation and shows promising crystal structure.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis, Crystal Structure and Antitumour Activity of 3-Amino-N-(5-Fluoro-2-Methylphenyl)-4-Morpholino-1H-Indazole-1-Carboxamide

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References

The disulfide compound α-lipoic acid and its derivatives: A novel class of anticancer agents targeting mitochondria.

-lipoic acid and its derivatives show promising anticancer activity by targeting mitochondria and displaying non-genotoxic properties, complementing established treatments.

Synthesis, Crystal Structure and bIological Activity of 5-(4-fluorophenyl)-N,N-dimethyl-7-(trifluoromethyl)Pyrazolo[1,5-a]Pyrimidine-3-carboxamide

5-(4-fluorophenyl)-N,N-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide effectively inhibits the proliferation of some cancer cell lines.

New macrocyclic analogs of the natural histone deacetylase inhibitor FK228; design, synthesis and preliminary biological evaluation.

Our novel FK228 analogs show promising cytotoxic and antitumor activity, with some showing low HDAC inhibition and others showing similar cytotoxic activities.

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5-chloro-3-(2,4-dichlorophenyl)-N-(3-methoxyphenyl)-2-methyl-6-phenylpyrazolo[1,5-A]pyrimidin-7-amine (C26H19Cl3N4O) demonstrates moderate

Synthesis, Crystal Structure, and Biological Activity of Diethyl-2-[5-(4-Fluorophenyl)-7-(Trifluoromethyl)Pyrazolo[1,5-a] Pyrimidine-3-Carboxamido]Pentanedioate

Diethyl-2-[5-(4-fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamido]pentanedioate] demonstrates moderate antituberculosis activity and

Citations

Synthesis, Crystal Structure and Antitumour Activity of 3-Amino-N-[4-chloro-3-(Trifluoromethyl)Phenyl]-4-Morpholino-1H-Indazole-1-Carboxamide

The compound 3-amino-N-[4-chloro-3-(trifluoromethyl)phenyl]-4-morpholino-1H-indazole-1-carboxamide shows antitumor activity against A549 and BGC-823 cancer cell lines.

Synthesis, Crystal Structure and Antitumour Activity of 4-(3-Amino-4-Morpholino-1H-Indazole-1-Carbonyl)Benzonitrile

4-(3-amino-4-morpholino-1H-indazole-1-carbonyl)benzonitrile shows some inhibition of cancer cell proliferation and has a crystal structure in the monoclinic system, space group P21/c.