Synthesis and Crystal Structure of 2-acetoxy-3-(3,4-diacetoxyphenyl) Propanoic Acid

doi:10.3184/174751916X14531217100725

Paper

Synthesis and Crystal Structure of 2-acetoxy-3-(3,4-diacetoxyphenyl) Propanoic Acid

Published Feb 1, 2016 · Lei Chen, B. Su, Jing Wang

Journal of Chemical Research

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Abstract

2-Acetoxy-3-(3,4-diacetoxyphenyl)propanoic acid has been synthesised as a derivative of 2-hydroxy-3-(3,4-dihydroxyphenyl)propanoic acid (danshensu) to improve its chemical stability and liposolubility. It was readily hydrolysed to release the bioactive danshensu. Its crystal structure and stereochemistry were determined by X-ray single crystal diffraction analysis.

Study Snapshot

2-Acetoxy-3-(3,4-diacetoxyphenyl)propanoic acid improves the chemical stability and liposolubility of danshensu, making it a promising bioactive compound.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and Crystal Structure of 2-acetoxy-3-(3,4-diacetoxyphenyl) Propanoic Acid

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References

Design, Synthesis, and Preliminary Cardioprotective Effect Evaluation of Danshensu Derivatives

Compound 14 shows significant cardioprotective effects, with a unique multifunctional mechanism of action, suggesting it may be a new potential therapy for ischemic heart diseases.

Neuroprotective effect of Danshensu derivatives as anti-ischaemia agents on SH-SY5Y cells and rat brain

Novel Danshensu derivatives show significant neuroprotective effects as anti-ischaemia agents, increasing cell viability and reducing infarct volume in rat brains.

The synthesis and biological evaluation of novel Danshensu-cysteine analog conjugates as cardiovascular-protective agents.

Novel Danshensu-cysteine analog conjugates show significant cardiovascular-protective effects, with potential mechanisms related to mitochondrial-protective effects and apoptosis-related proteins.

X-ray crystal structure of iridoid glucoside aucubin and its aglycone.

The crystal structures of iridoid glycoside aucubin and its aglycone aucubigenin reveal orthorhombic and monoclinic structures, with intense O-HO hydrogen bonds in both structures.

Asymmetric synthesis and biological evaluation of Danshensu derivatives as anti-myocardial ischemia drug candidates.

Danshensu derivatives show potential as anti-myocardial ischemia drugs due to their protective activities against hypoxia-induced cellular damage and anti-apoptosis effects.

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