Synthesis, crystal structure, and biological evaluation of ethyl 9-(2-fluorobenzyl)-1-phenyl-9 h-pyrido[3,4-b]indole-3-carboxylate as anticancer agent

doi:10.1080/15421406.2017.1358014

Paper

Synthesis, crystal structure, and biological evaluation of ethyl 9-(2-fluorobenzyl)-1-phenyl-9 h-pyrido[3,4-b]indole-3-carboxylate as anticancer agent

Published Jul 24, 2017 · M. Mohideen, N. Kamaruzaman, M. Rosli

Molecular Crystals and Liquid Crystals

2

Citations

0

Influential Citations

Full text

Abstract

ABSTRACT An efficient method was described for the synthesis of ethyl 9-(2-fluorobenzyl)-1-phenyl-9 H-pyrido[3,4-b]indole-3-carboxylate from the starting material L-tryptophan in good yield. The structure of the synthesised compound was established by 1H-NMR, 13C-NMR, and mass spectrometry, as well as single crystal X-ray diffraction analysis. The synthesised compound was screened for it's in vitro anticancer activity against four human carcinoma cell lines by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results showed that the synthesised compound generated a low IC50 value of 14.2 µM in human chronic myelogenous leukaemia (CML) K562 cell line, suggesting that this compound has the potential to be developed further for its anticancer activity.

In Vitro Study

Study Snapshot

Ethyl 9-(2-fluorobenzyl)-1-phenyl-9 H-pyrido[3,4-b]indole-3-carboxylate shows potential anticancer activity against human chronic myelogenous leukemia K562 cells, with a low

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis, crystal structure, and biological evaluation of ethyl 9-(2-fluorobenzyl)-1-phenyl-9 h-pyrido[3,4-b]indole-3-carboxylate as anticancer agent

References

Citations