Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic Acids

doi:10.15826/chimtech.2023.10.1.02

Paper

Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic Acids

Published Dec 16, 2022 · S. N. Igidov, D. V. Lipin, A. Turyshev

Chimica Techno Acta

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Abstract

A method was proposed for the synthesis of substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids by the reaction of substituted 2,4-dioxobut-2-enoic acids with furan-2-carbohydrazide. It was found that substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids undergo intramolecular cyclization in the presence of propionic anhydride to form the corresponding N'-(2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides. The anti-inflammatory activity of the obtained compounds was studied. It was found that the obtained compounds have pronounced anti-inflammatory activity.

Study Snapshot

Substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids show pronounced anti-inflammatory activity when synthesized using the proposed method.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic Acids

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References

Medicinal Chemistry Strategies to Extend Duration of Action of Inhaled Drugs for Intracellular Targets.

This paper highlights key properties and strategies for designing inhaled drugs with intracellular targets, providing guidance for medicinal chemistry teams to extend their duration of action.

Synthesis of highly stable luminescent molecular crystals based on (E)-2-((3-(ethoxycarbonyl)-5-methyl-4-phenylthiophen-2-yl)amino)-4-oxo-4-(p-tolyl)but-2-enoic acid

This study successfully synthesized highly stable luminescent molecular crystals based on (E)-2-((3-(ethoxycarbonyl)-5-methyl-4-phenylthiophen-2-yl)amino)-4-oxo-4-(p-tolyl)

Advances in Antifungal Drug Development: An Up-To-Date Mini Review

Antifungal drug development is progressing with novel structures, formulation modifications, and immunotherapy, aiming to overcome resistance and improve clinical utility.

The influence of substitutes on the room temperature photoluminescence of 2-amino-4-oxobut-2-enoic acid molecular crystals

Tuning the structure of 2-amino-4-oxobut-2-enoic acid during synthesis allows for high structural rigidity and red photoemission, enabling their use in organic optoelectronics and photonics.

Diverse coordination of isoniazid hydrazone Schiff base ligand towards iron(III): Synthesis, characterization, SC-XRD, HSA, QTAIM, MEP, NCI, NBO and DFT study

A new iron(III) complex has been successfully prepared by reacting isoniazid hydrazone Schiff base ligand with Fe(acac) 3, revealing diverse coordination patterns and distorted octahedral geometry.

Synthesis and Intramolecular Cyclization of Substituted 4-(Het)aryl-4-oxo-2-thienylaminobut-2-enoic Acids Containing Nitrile Group in the Thiophene Ring

This study proposes a method for synthesizing substituted 4-(het)aryl-4-oxo-2-thienylaminobut-2-enoic acids with nitrile substituents, leading to new substituted 3-thienylimino-3H-furan-2-one

Straightforward synthesis of novel spiroether derivatives

Novel spiroether derivatives synthesized via 4-oxobut-2-enoates and alloxan show moderate growth inhibitory effects on human cancer cell lines.

Synthesis and Hemostatic, Anti-Inflammatory, and Anthelminthic Activity of 2-hydroxy-4-oxo-4-(thien-2-yl)but-2-enoic Acid Derivatives

Hetarylammonium 2-hydroxy-4-oxo-4-(thien-2-yl)but-2-enoates show potential as hemostatic and anthelminthic agents, with promising anti-inflammatory activity.

Citations