Synthesis and cytotoxic activity of novel 3-(1H-indol-3-yl)-1H-pyrazole-5-carbohydrazide derivatives.

doi:10.1016/j.ejmech.2011.09.049

Paper

Synthesis and cytotoxic activity of novel 3-(1H-indol-3-yl)-1H-pyrazole-5-carbohydrazide derivatives.

Published Dec 1, 2011 · Datong Zhang, G. Wang, Guilong Zhao

European journal of medicinal chemistry

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39

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Abstract

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In Vitro Study

Study Snapshot

Novel 3-(1H-indole-3-yl)-1H-pyrazole-5-carbohydrazide derivatives show more potent antiproliferative activity against human cancer cell lines than 5-fluorourcail, arresting the cell cycle at S phase.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and cytotoxic activity of novel 3-(1H-indol-3-yl)-1H-pyrazole-5-carbohydrazide derivatives.

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