Synthesis and DHFR inhibitory activity of a series of 6-substituted-2,4-diaminothieno[2,3-d]pyrimidines.

doi:10.1016/S0223-5234(03)00101-6

Paper

Synthesis and DHFR inhibitory activity of a series of 6-substituted-2,4-diaminothieno[2,3-d]pyrimidines.

Published Jun 1, 2003 · I. Donkor, Hui Li, S. Queener

European journal of medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

6-aralkyl substituted 2,4-diaminothieno[2,3-d]pyrimidines show potent and selective inhibition of dihydrofolate reductase from various pathogens.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and DHFR inhibitory activity of a series of 6-substituted-2,4-diaminothieno[2,3-d]pyrimidines.

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