Stereoselective synthesis of diazaspiro[5.5]undecane derivatives via base promoted [5+1] double Michael addition of N,N-dimethylbarbituric acid to diaryliedene acetones

doi:10.1016/J.ARABJC.2015.03.007

Paper

Stereoselective synthesis of diazaspiro[5.5]undecane derivatives via base promoted [5+1] double Michael addition of N,N-dimethylbarbituric acid to diaryliedene acetones

Published 2017 · M. Islam, A. Barakat, A. Barakat

Arabian Journal of Chemistry

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10

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Abstract

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Study Snapshot

This study developed a new method for stereoselective synthesis of diazaspiro[5.5]undecane derivatives with excellent yields (up to 98%) from easily accessible symmetric and non-symmetric divinylketones, revealing their structural elucidation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Stereoselective synthesis of diazaspiro[5.5]undecane derivatives via base promoted [5+1] double Michael addition of N,N-dimethylbarbituric acid to diaryliedene acetones

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