Synthesis of Dibenzyls by Nickel-Catalyzed Homocoupling of Benzyl Alcohols

doi:10.1055/a-1467-2432

Paper

Synthesis of Dibenzyls by Nickel-Catalyzed Homocoupling of Benzyl Alcohols

Published Mar 25, 2021 · Xing‐Zhong Shu, F. Pan, P. Guo

Synthesis

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Abstract

Abstract Dibenzyls are essential building blocks that are widely used in organic synthesis, and they are typically prepared by the homocoupling of halides, organometallics, and ethers. Herein, we report an approach to this class of compounds using alcohols, which are more stable and readily available. The reaction proceeds via nickel-catalyzed and dimethyl oxalate assisted dynamic kinetic homocoupling of benzyl alcohols. Both primary and secondary alcohols are tolerated.

Study Snapshot

Nickel-catalyzed homocoupling of benzyl alcohols allows for the synthesis of stable and readily available dibenzyls, making them a valuable building block in organic synthesis.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Synthesis of Dibenzyls by Nickel-Catalyzed Homocoupling of Benzyl Alcohols

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Citations

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