Synthesis and distribution of N‐benzyloxycarbonyl‐[14C]‐glycine, a lipophilic derivative of glycine

doi:10.1002/JLCR.2580360414

Paper

Synthesis and distribution of N‐benzyloxycarbonyl‐[14C]‐glycine, a lipophilic derivative of glycine

Published Apr 1, 1995 · D. Lambert, B. Gallez, Jacques Poupaert

Journal of Labelled Compounds and Radiopharmaceuticals

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Abstract

N-benzyloxycarbonyl[C-14]-glycine, a lipophilic derivative of glycine exhibiting anticonvulsant properties, was prepared in one step from [U-C-14] glycine and benzyl chloroformate in alkali medium. A comparative study of biodistribution was carried on mice between this compound and the parent amino-acid after intravenous administration. Dimethylsulfoxide was used as injection vehicle for N-benzyloxycarbonylglycine. The influence of this injection vehicle was studied comparing glycine injected in a saline solution and glycine co-administered with dimethylsulfoxide. No significant difference was found between these two treatments. Compared to glycine, N-benzyloxycarbonylglycine reached quickly the central nervous system and exhibited an enhanced brain penetration index, 13-fold superior to the parent aminoacid value.

Non-RCTAnimal Study

Study Snapshot

N-benzyloxycarbonyl[C-14]-glycine, a lipophilic derivative of glycine, exhibits anticonvulsant properties and a faster central nervous system penetration compared to glycine.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and distribution of N‐benzyloxycarbonyl‐[14C]‐glycine, a lipophilic derivative of glycine

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