Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents.

doi:10.1016/S0960-894X(02)00940-X

Paper

Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents.

Published Feb 10, 2003 · L. Hsin, T. Prisinzano, Chavon R. Wilkerson

Bioorganic & medicinal chemistry letters

Q2 SJR score

15

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1

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Abstract

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In Vitro Study

Study Snapshot

Chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines show high affinity and selectivity for dopamine transporter, making them potential candidates for long-acting cocaine abuse therapeutic agents.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents.

References

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