Synthesis and elaboration of N-methylpyrrolidone as an acetamide fragment substitute in bromodomain inhibition.

doi:10.1016/j.bmc.2019.115157

Paper

Synthesis and elaboration of N-methylpyrrolidone as an acetamide fragment substitute in bromodomain inhibition.

Published Oct 28, 2019 · J. P. Hilton-Proctor, O. Ilyichova, Z. Zheng

Bioorganic & medicinal chemistry

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9

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Abstract

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Study Snapshot

N-methylpyrrolidone shows potential as a lead in bromodomain inhibition, showing comparable binding affinity and structural mimicry to Olinone in the bromodomain binding site.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and elaboration of N-methylpyrrolidone as an acetamide fragment substitute in bromodomain inhibition.

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