Ethyl (S)-2-ethoxy-3-(4-hydroxyphenyl)propionate was synthesized from L-tyrosine by O- benzylation and diazotization to give (S)-2-hydroxy-3-(4-benzyloxyphenyl)propionic acid, which was subjected to O-ethylation and esterifi cation followed by catalytic hydrogenated debenzylation with an overall yield of 19% and 98.5%ee.

Ethyl (S)-2-ethoxy-3-(4-hydroxyphenyl) propionate was synthesized from L-tyrosine with a 19% yield and 98.5%ee, providing potential as a pharmaceutical intermediate.

Paper

Synthesis of Ethyl (S)-2-Ethoxy-3-(4-hydroxyphenyl) propionate

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