Paper

Synthesis and evaluation of the 2,4-diaminoquinazoline series as anti-tubercular agents.

Published Dec 15, 2014 · J. Odingo, T. O’Malley, E. Kesicki

Bioorganic & medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

The 2,4-diaminoquinazoline series shows potential as a lead candidate for tuberculosis drug discovery, with bactericidal activity against both replicating and non-replicating Mycobacterium tuberculosis, and good in vivo exposure achievable.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and evaluation of the 2,4-diaminoquinazoline series as anti-tubercular agents.

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