Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors.

doi:10.1016/j.bmcl.2009.02.067

Paper

DOI: 10.1016/j.bmcl.2009.02.067

Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors.

Published Apr 15, 2009 · R. Lin, Sigmond G. Johnson, P. Connolly

Bioorganic & medicinal chemistry letters

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105

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2,7-diamino-thiazolo[4,5-d] pyrimidine analogues show potent and selective EGFR inhibitory activities, inhibiting cellular proliferation in EGFR-overexpressing human tumor cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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