Synthesis and fungicidal evaluation of 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives.

doi:10.1021/jf900222s

Paper

Synthesis and fungicidal evaluation of 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives.

Published Jun 10, 2009 · Guan‐Ping Yu, Liang-zhong Xu, Xu Yi

Journal of agricultural and food chemistry

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Abstract

A series of novel 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives were designed and synthesized as candidate fungicides. The new compounds were identified by (1)H NMR spectroscopy and element analysis. Their antifungal activities were evaluated. They exhibited excellent antifungal activities against five common pathogens in comparison with the commercial fungicides tebuconazole and difenoconazole. The antifungal activities of three new triazole alcohol compounds were compared with those of tebuconazole and difenoconazole at a concentration of 1 mug/mL.

In Vitro Study

Study Snapshot

Novel 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives show excellent antifungal activities against common pathogens, outperforming commercial fungicides tebuconazole and difenoconazole

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and fungicidal evaluation of 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives.

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References

Effectiveness of systemic fungicides in the control of Quambalaria eucalypti and their effects on production of eucalypt mini-cuttings for rooting

Systemic fungicides effectively control Quambalaria eucalypti in mini-clonal hedges, but epoxiconazole+pyraclostrobin negatively affects mini-cutting production.

Synthesis and antifungal activity of a series of N-substituted [2-(2,4-dichlorophenyl)-3-(1,2,4-triazol-1-yl)]propylamines.

N-substituted [2-(2,4-dichlorophenyl)-3-(1,2,4-triazol-1-yl)]propylamines and amides show promising antifungal activity against plant pathogenic fungi, with allyl, propargyl,

Synthesis and herbicidal activity of N,N-diethyl-3-(arylselenonyl)-1H-1,2,4-triazole-1-carboxamide.

Novel selenium-containing compounds show good inhibitory activity against cucumber and semen euphorbiae, with higher selectivity between weed and rice than Cafenstrole.

Synthesis and antifungal action of new tricyclazole analogues.

New tricyclazole analogues show less efficient antifungal activity than tricyclazole, with a different mechanism of action.

Synthesis, fungicidal activity, and QSAR of a series of 2-dichlorophenyl-3-triazolylpropyl ethers.

New 2-dichlorophenyl-3-triazolylpropyl ethers show broad spectrum of activity and efficacy against common pathogens, with lipophilicity and mu being key factors in affecting activity.

Citations

Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

Fluconazole derivatives with modifications in hydroxyl, aromatic, and 1,2,4-triazole rings can enhance antifungal effectiveness and improve pharmacokinetic parameters and safety profiles.

Expedient Discovery for Novel Antifungal Leads Targeting Succinate Dehydrogenase: Pyrazole-4-formylhydrazide Derivatives Bearing a Diphenyl Ether Fragment.

Novel pyrazole-4-formylhydrazine derivatives bearing a diphenyl ether moiety show excellent antifungal effects against Rhizoctonia solani, Fusarium graminearum, and Botrytis cinerea, with potential as a new fungicide targeting

Iizukines C-E from a saline soil fungus Aspergillus iizukae.

Iizukines C-E, a new alkaloid from Aspergillus iizukae, show cytotoxic effects against HL-60 and A549 cell lines with IC 50 values of 3.8 and 7.2 M, respectively.

Fluconazole-Pyridoxine Bis-Triazolium Compounds with Potent Activity against Pathogenic Bacteria and Fungi Including Their Biofilm-Embedded Forms

Fluconazole-pyridoxine bis-triazolium compounds show potent activity against pathogenic bacteria and fungi, including their biofilm-embedded forms, with potential for new broad-spectrum antimicrobial therapies.

Synthesis of novel fenfuram-diarylether hybrids as potent succinate dehydrogenase inhibitors.

Novel fenfuram-diarylether hybrids show potent antifungal effects against Rhizoctonia solani and Sclerotinia sclerotiorum, with compound 1c showing the most potent effect on R. solani.