3-(4-Chlorophenyl)-4-substituted pyrazole derivatives were synthesised and tested for their in vitro antifungal activity. Some compounds showed very good antifungal activity against four pathogenic strains of fungi. The same compounds exhibited an interesting activity against the tested strain of Mycobacterium tuberculosis H37Rv. The results suggest that 1,3,4-oxadiazoles and 5-pyrazolinones bearing a core pyrazole scaffold may be promising antifungal and antitubercular agents.

3-(4-chlorophenyl)-4-substituted pyrazole derivatives show promising antifungal and antitubercular activity against pathogenic fungi and Mycobacterium tuberculosis H37Rv.

Paper

Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives.

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