Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB(2) agonists for the treatment of inflammatory pain.

doi:10.1016/j.bmcl.2009.11.117

Paper

Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB(2) agonists for the treatment of inflammatory pain.

Published Jan 15, 2010 · Robert J Gleave, P. Beswick, Andrew J. Brown

Bioorganic & medicinal chemistry letters

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43

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Abstract

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Study Snapshot

3-amino-6-aryl-pyridazines show high efficacy and selectivity as CB2 agonists for treating inflammatory pain, with pyridazine analogue 35 showing high potency in an in vivo model.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB(2) agonists for the treatment of inflammatory pain.

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