Synthesis and preliminary evaluation of 3-thiocyanato-1H-indoles as potential anticancer agents.

doi:10.1016/j.ejmech.2016.04.039

Paper

Synthesis and preliminary evaluation of 3-thiocyanato-1H-indoles as potential anticancer agents.

Published Aug 8, 2016 · Margiani P. Fortes, Paulo da Silva, T. G. da Silva

European journal of medicinal chemistry

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57

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1

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Abstract

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In Vitro Study

Study Snapshot

3-thiocyanato-1H-indoles show good to excellent anticancer activity, with N-phenyl-3-thiocyanato-1H-indole showing the highest potency against human cancer cell lines.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and preliminary evaluation of 3-thiocyanato-1H-indoles as potential anticancer agents.

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References

Citations

Copper-Catalyzed 1,5-Trifluoromethyl-thio(seleno)cyanation of 5-Hexenenitriles with an Intramolecular Cyano Migration.

Copper-catalyzed remote 1,5-trifluoromethyl thio(seleno)cyanation of 5-hexenenitriles with intramolecular cyano migration produces various CF3/CN-containing thiocyanates and selenocyanates under mild conditions with high

Crystal Structure of 3-Methyl-2,6-diphenyl-1-(2-thiocyanatoacetyl)piperidin-4-one: A Combined Experimental and Theoretical Study

The crystal structure of 3-methyl-2,6-diphenyl-1-(2-thiocyanatoacetyl)piperidin-4-one reveals its structural and therapeutic significance, supporting its anticancer potential and drug development potential.

Electrochemical Desaturation and β-Thiocyanation of Cyclic Amides.

This study presents an electrochemical desaturation and -thiocyanation method for bioactive molecules, exhibiting broad functional group tolerance, excellent selectivity, and mild reaction conditions.

Electrochemical synthesis of isothiocyanogen and its reactivity in thiocyanation reactions

Electrochemical oxidation of (iso)thiocyanic acid leads to isothiocyanogen, a novel compound with high reactivity in thiocyanation reactions.

Visible-Light-Mediated, Organophotocatalytic C-H Thiocyanation of Pyrazolo[1,5-a]pyrimidines.

This study presents a metal-free, organophotoredox-catalyzed sustainable C-H thiocyanation of pyrazolo[1,5-a]pyrimidines using potassium thiocyanate under blue-light-emitting diode irradiation at room

A Review of Recent Progress on the Anticancer Activity of Heterocyclic Compounds

Heterocyclic compounds show potential anticancer activity, including quinolines, pyrroles, pyrimidines, pyridines, indoles, and sulfonamides linked heterocycles.

Aerobic Catalytic Cross-Dehydrogenative Coupling of Furans with Indoles Provides Access to Fluorophores with Large Stokes Shift.

Cross-dehydrogenative coupling of furans with indoles using inexpensive FeCl3 6H2O catalyst in oxygen-rich conditions produces scalable, sustainable, and economical fluorophores with large Stokes shifts.