Synthesis and biological evaluation of (4-(trifluoromethyl)-hexahydro-4-hydroxy-1-methyl-6-aryl-2-thioxopyrimidin-5-yl)(4-methoxyphenyl)methanone derivatives

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Synthesis and biological evaluation of (4-(trifluoromethyl)-hexahydro-4-hydroxy-1-methyl-6-aryl-2-thioxopyrimidin-5-yl)(4-methoxyphenyl)methanone derivatives

Published 2012 · Parthiv K. Chaudhari

Organic Chemistry: An Indian Journal

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Abstract

The synthesis of (4-(trifluoromethyl)-hexahydro-4-hydroxy-1-methyl-6-aryl- 2-thioxopyrimidin-5-yl)(4-methoxyphenyl)methanone can be achieved from amixture of 4,4,4-trifluoro-1-(4-methylphenyl)butane-1,3-dione, an appropriate aldehyde, N-methylthiourea and catalytically amount of concentrated hydrochloric acid in ethanol was heated under reflux condition. Elemental analysis, IR, 1H-NMR, and mass spectral data established identification of the compounds. Products were evaluated for their antimicrobial activity using cup plate method[1]. Some of the obtained compounds showed the interesting antimicrobial activity.

Study Snapshot

The synthesis of (4-(trifluoromethyl)-hexahydro-4-hydroxy-1-methyl-6-aryl-2-thioxopyrimidin-5-yl)(4-methoxyphenyl)methanone derivatives yields compounds with interesting antimicrobial activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis and biological evaluation of (4-(trifluoromethyl)-hexahydro-4-hydroxy-1-methyl-6-aryl-2-thioxopyrimidin-5-yl)(4-methoxyphenyl)methanone derivatives

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