Synthesis and antiproliferative evaluation of certain 4-anilino-8-methoxy-2-phenylquinoline and 4-anilino-8-hydroxy-2-phenylquinoline derivatives.

doi:10.1016/J.BMC.2005.12.017

Paper

DOI: 10.1016/J.BMC.2005.12.017

Synthesis and antiproliferative evaluation of certain 4-anilino-8-methoxy-2-phenylquinoline and 4-anilino-8-hydroxy-2-phenylquinoline derivatives.

Published May 1, 2006 · Yeh‐long Chen, Chao-Jhieh Huang, Zun-Yuan Huang

Bioorganic & medicinal chemistry

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Abstract

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In Vitro Study

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4-anilino-8-methoxy-2-phenylquinoline and 4-anilino-8-hydroxy-2-phenylquinoline derivatives show antiproliferative activity, with compound 11 showing particularly active against solid cancer cells, due to accumulation in S-phase.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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