Synthesis and evaluation of diphenylphosphinic amides and diphenylphosphine oxides as inhibitors of Kv1.5.

doi:10.1016/j.bmcl.2012.11.098

Paper

Synthesis and evaluation of diphenylphosphinic amides and diphenylphosphine oxides as inhibitors of Kv1.5.

Published Feb 1, 2013 · Roine I. Olsson, I. Jacobson, Jonas Boström

Bioorganic & medicinal chemistry letters

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21

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0

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Abstract

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Study Snapshot

Diphenylphosphinic amides and diphenylphosphine oxides show potential as Kv1.5 potassium ion channel inhibitors for atrial fibrillation treatment, with selectivity over ventricular IKs current.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis and evaluation of diphenylphosphinic amides and diphenylphosphine oxides as inhibitors of Kv1.5.

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