Synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl acetamides and ethyl acetates as potent COX-2 inhibitors.

doi:10.1016/j.bmc.2014.12.041

Paper

Synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl acetamides and ethyl acetates as potent COX-2 inhibitors.

Published Feb 15, 2015 · S. Consalvi, S. Alfonso, A. Di Capua

Bioorganic & medicinal chemistry

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21

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Abstract

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In Vitro Study

Study Snapshot

New methylsulfonyl, sulfamoyl acetamides, and ethyl acetates show potential as selective COX-2 inhibitors with good analgesic activity and stability.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl acetamides and ethyl acetates as potent COX-2 inhibitors.

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