Synthesis, biological evaluation, and docking studies of novel 5,6-diaryl-1,2,4-triazine thiazole derivatives as a new class of α-glucosidase inhibitors.

doi:10.1016/j.bioorg.2018.03.015

Paper

DOI: 10.1016/j.bioorg.2018.03.015

Synthesis, biological evaluation, and docking studies of novel 5,6-diaryl-1,2,4-triazine thiazole derivatives as a new class of α-glucosidase inhibitors.

Published Aug 1, 2018 · Guangcheng Wang, Zhiyun Peng, Zipeng Gong

Bioorganic chemistry

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

Novel 5,6-diaryl-1,2,4-triazine thiazole derivatives show promising -glucosidase inhibitory activity, with compound 7i showing the highest activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Design, synthesis, biological evaluation, and molecular modeling studies of some quinazolin-4(3H)-one-benzenesulfonamide hybrids as potential α-glucosidase inhibitors.

Novel quinazolin-4(3H)-one-benzenesulfonamide hybrid compounds show potential as effective -glucosidase inhibitors for diabetes treatment, with compound 10 showing the most activity.

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Investigating the Efficacy of Naphthalene-Thiazole Hybrid hydrazones as α-Glucosidase Inhibitors

Naphthalene-thiazole hybrid hydrazones show diverse inhibitory potentials as -glucosidase inhibitors, with compounds 4d, 4e, 4c, and 8 showing the strongest binding affinities.

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