Synthesis and biological evaluation of new dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones, substituted with various saturated and unsaturated side chains via palladium catalyzed cross-coupling reactions.

doi:10.1016/J.BMC.2006.01.030

Paper

Synthesis and biological evaluation of new dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones, substituted with various saturated and unsaturated side chains via palladium catalyzed cross-coupling reactions.

Published Jun 1, 2006 · H. Hénon, F. Anizon, R. Golsteyn

Bioorganic & medicinal chemistry

Q2 SJR score

24

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Abstract

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In Vitro Study

Study Snapshot

These dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones show inhibitory activity against Chk1 kinase and antiproliferative activities in vitro in tumor cell lines.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and biological evaluation of new dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones, substituted with various saturated and unsaturated side chains via palladium catalyzed cross-coupling reactions.

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