Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents.

doi:10.1016/j.bmcl.2013.02.029

Paper

DOI: 10.1016/j.bmcl.2013.02.029

Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents.

Published Apr 15, 2013 · Rania Hamdy, N. Ziedan, Samia Ali

Bioorganic & medicinal chemistry letters

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Abstract

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In Vitro Study

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Substituted 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines show potential as pro-apoptotic Bcl-2 inhibitory anticancer agents, with Bcl-2 being a potential mo

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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