Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents.

doi:10.1016/j.ejmech.2012.09.034

Paper

Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents.

Published Nov 1, 2012 · Pawel M Lukasik, Sherifa Elabar, F. Lam

European journal of medicinal chemistry

Q2 SJR score

65

Citations

1

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

Imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives show potent anti-cancer properties, with a lead compound 18b demonstrating the ability to reduce Mcl-1 protein and induce cancer cell apoptosis.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents.

References

Citations