Paper

Synthesis and biological evaluation of isoxazoline derivatives as potent M₁ muscarinic acetylcholine receptor agonists.

Published Apr 1, 2015 · Minghua Huang, D. Suk, Nam-Chul Cho

Bioorganic & medicinal chemistry letters

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Abstract

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In Vitro Study

Study Snapshot

Isoxazoline derivatives show potent and selective M1 muscarinic acetylcholine receptor agonist activity, potentially benefiting Alzheimer's disease treatment.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and biological evaluation of isoxazoline derivatives as potent M₁ muscarinic acetylcholine receptor agonists.

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