Synthesis and biological evaluation of kresoxim-methyl analogues as novel inhibitors of hypoxia-inducible factor (HIF)-1 accumulation in cancer cells.

doi:10.1016/j.bmcl.2017.05.024

Paper

Synthesis and biological evaluation of kresoxim-methyl analogues as novel inhibitors of hypoxia-inducible factor (HIF)-1 accumulation in cancer cells.

Published Jul 1, 2017 · Sanghyuck Lee, O. S. Kwon, Chang-Soo Lee

Bioorganic & medicinal chemistry letters

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17

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Abstract

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In Vitro Study

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Kresoxim-methyl analogues show potent inhibitory activity against hypoxia-induced HIF-1 activation in cancer cells, increasing intracellular oxygen levels and potentially improving cancer cell survival.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis and biological evaluation of kresoxim-methyl analogues as novel inhibitors of hypoxia-inducible factor (HIF)-1 accumulation in cancer cells.

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