Paper

Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors.

Published Dec 15, 2010 · Yisheng Lai, Lin Ma, Wen-long Huang

Bioorganic & medicinal chemistry letters

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Abstract

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In Vitro Study

Study Snapshot

New 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives show potent inhibitory activities against COX-1/2 and 5-LOX, with potential for designing safe anti-inflammatory treatments for rheumatoid arthritis.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors.

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