Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase.

doi:10.1016/j.bmc.2013.05.001

Paper

Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase.

Published Jul 15, 2013 · Jinmei Zhu, Chun-Feng Wu, Xiaobing Li

Bioorganic & medicinal chemistry

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45

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Abstract

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In Vitro Study

Study Snapshot

2-aminobenzimidazole drugs show promising new selective inhibitors for acetylcholinesterase and butyrylcholinesterase, potentially useful for treating neurodegenerative diseases.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase.

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References

Citations

Exploring the Benzazoles Derivatives as Pharmacophores for AChE, BACE1, and as Anti-Aβ Aggregation to Find Multitarget Compounds against Alzheimer’s Disease

Benzothiazoles and benzimidazoles show potential as multitarget drugs for Alzheimer's disease by inhibiting AChE and BACE1, and inhibiting A aggregation.

Novel Synthesis of Functionalized Bis(Benzo‐Heterocyclic Amine) Derivatives via Copper‐Catalyzed One‐Pot Multicomponent Reactions

Copper-catalyzed one-pot synthesis of bis(benzoxazole)amine, N-benzoxazole(benzoimidazole)amine, and N-benzoxazole(benzothiazole)amine yields 74-84% of new compounds with simple starting materials and

A Review of Approaches to the Metallic and Non-Metallic Synthesis of Benzimidazole (BnZ) and Their Derivatives for Biological Efficacy

This review highlights the potential of metallic and non-metallic benzimidazole (BnZ) and their derivatives for anti-cancer, anti-inflammatory, anti-microbial, anti-tubercular, and anti-protozoal properties in pharmaceuticals.

Design, synthesis and molecular docking studies of 5-fluoro 1-aryl/alkyl sulfonyl benzimidazole derivatives for treatment of Parkinson’s disease

Fluoro-substituted benzimidazole derivatives show higher binding affinity toward MAO-B, potentially offering potential for Parkinson's disease treatment and antibacterial activity.

Metal-free methods for the generation of benzimidazoles and 2-aminobenzimidazoles

Metal-free synthesis of benzimidazoles and 2-aminobenzimidazoles offers a sustainable approach for benzimidazole ring formation, with potential applications in biologically important molecules.

Ionic signalling mechanisms involved in neurokinin‐3 receptor‐mediated augmentation of fear‐potentiated startle response in the basolateral amygdala

NK3R activation in the basolateral amygdala increases fear-potentiated startle response by excitating neurons and enhancing the ion channel-mediated signaling pathway.

The biological activities of butyrylcholinesterase inhibitors.

Butyrylcholinesterase inhibitors show better curative effects and lower side effects than specific AChE inhibitors for Alzheimer's disease treatment.

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Benzimidazole derivatives show promising pharmacological properties against various diseases, with promising therapeutic candidates undergoing human trials.

Synthesis, investigation of biological effects and in silico studies of new benzimidazole derivatives as aromatase inhibitors

New benzimidazole derivatives show potential as aromatase inhibitors, with the most potent compounds being 4-benzylpiperidine derivatives 2c, 2g, and 2k, showing anticancer activity against human A549 and MCF-7 cell lines.