Synthesis, biological evaluation and molecular modelling studies of 1,3,7,8-tetrasubstituted xanthines as potent and selective A2A AR ligands with in vivo efficacy against animal model of Parkinson's disease.

doi:10.1016/j.bioorg.2019.03.032

Paper

Synthesis, biological evaluation and molecular modelling studies of 1,3,7,8-tetrasubstituted xanthines as potent and selective A2A AR ligands with in vivo efficacy against animal model of Parkinson's disease.

Published Jun 1, 2019 · Suman Rohilla, R. Bansal, S. Kachler

Bioorganic chemistry

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5

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Abstract

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In Vitro Study

Study Snapshot

1,3,7,8-tetrasubstituted xanthines show potential as potent and selective A2A adenosine receptor ligands for Parkinson's disease treatment, with 1,3-Dipropylxanthine 7a showing the highest affinity and antiparkins

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis, biological evaluation and molecular modelling studies of 1,3,7,8-tetrasubstituted xanthines as potent and selective A2A AR ligands with in vivo efficacy against animal model of Parkinson's disease.

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