Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists.

doi:10.1016/j.bmc.2014.12.011

Paper

Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists.

Published Jul 15, 2015 · Martin Hansen, Stine E. Jacobsen, S. Plunkett

Bioorganic & medicinal chemistry

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21

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Abstract

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In Vitro Study

Study Snapshot

N-benzyl substitution in 4-bromo-2,5-dimethoxyphenethylamine derivatives can significantly influence binding affinity and receptor selectivity, but generally leads to less efficacious agonists than previously reported.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists.

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