Paper

Synthesis and biological evaluation of novel 7-substituted 3-(4-phenoxyphenyl)thieno[3,2-c]pyridin-4-amines as potent Bruton's tyrosine kinase (BTK) inhibitors.

Published Oct 1, 2015 · Minhang Xin, Xinge Zhao, Wei Huang

Bioorganic & medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

Novel 7-substituted 3-(4-phenoxyphenyl)thieno[3,2-c]pyridin-4-amines show potent Bruton's tyrosine kinase inhibitory activity, with compound 13b showing excellent potency and good kinas

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and biological evaluation of novel 7-substituted 3-(4-phenoxyphenyl)thieno[3,2-c]pyridin-4-amines as potent Bruton's tyrosine kinase (BTK) inhibitors.

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