Synthesis and biological evaluation of novel exo-methylene cyclopentanone tetracyclic diterpenoids as antitumor agents.

doi:10.1016/j.bmcl.2010.11.055

Paper

Synthesis and biological evaluation of novel exo-methylene cyclopentanone tetracyclic diterpenoids as antitumor agents.

Published 2011 · Jing Li, Dayong Zhang, Xiao-ming Wu

Bioorganic & medicinal chemistry letters

Q2 SJR score

42

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1

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Abstract

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In Vitro Study

Study Snapshot

Novel exo-methylene cyclopentanone tetracyclic diterpenoids show potent and selective antitumor activity, with compounds 2b and 3b showing the most potent and selective activity against Hep-G2 and MDA-MB-231 cancer cell lines.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and biological evaluation of novel exo-methylene cyclopentanone tetracyclic diterpenoids as antitumor agents.

References

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