Synthesis and biological evaluation of novel phthalazinone derivatives as topically active phosphodiesterase 4 inhibitors.

doi:10.1016/j.bmc.2009.08.014

Paper

Synthesis and biological evaluation of novel phthalazinone derivatives as topically active phosphodiesterase 4 inhibitors.

Published Oct 1, 2009 · Kohei Kagayama, T. Morimoto, Seigo Nagata

Bioorganic & medicinal chemistry

Q2 SJR score

32

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

Benzylamine-substituted phthalazinones are potent PDE4 inhibitors that effectively suppress TNF- production and show potential as topical treatments for dermatitis.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and biological evaluation of novel phthalazinone derivatives as topically active phosphodiesterase 4 inhibitors.

References

Citations