Synthesis and anti-HIV evaluation of some phosphoramidate derivatives of AZT: studies on the effect of chain elongation on biological activity.

doi:10.1016/0166-3542(90)90053-A

Paper

DOI: 10.1016/0166-3542(90)90053-A

Synthesis and anti-HIV evaluation of some phosphoramidate derivatives of AZT: studies on the effect of chain elongation on biological activity.

Published Dec 1, 1990 · Duncan Curley, Christopher McGuigan, K. G. Devine

Antiviral research

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Study Snapshot

Terminal substituted alkyl amines of AZT show a pronounced anti-HIV effect, declining with increasing chain length, suggesting a mechanism of action involving intracellular cleavage of phosphoramidate bonds.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1177/095632029000100205

Synthesis and Evaluation of Some Novel Phosphoramidate Derivatives of 3′-Azido-3′-Deoxythymidine (AZT) as Anti-HIV Compounds

Novel phosphoramidate derivatives of AZT show significant anti-HIV activity, with activity influenced by the structure of the phosphate moiety and the amino acid nature.

1990·49citations·C. Mcguigan* et al.·Antiviral Chemistry and Chemotherapy

Antiviral Chemistry and Chemotherapy

DOI: 10.1177/095632029000100105

Synthesis of Some Novel Dialkyl Phosphate Derivatives of 3′-Modified Nucleosides as Potential Anti-AIDS Drugs

Novel 3′-modified nucleosides show no anti-HIV activity in vitro, due to the metabolic stability of the trialkyl phosphate moiety.

1990·40citations·C. Mcguigan* et al.·Antiviral Chemistry and Chemotherapy

Antiviral Chemistry and Chemotherapy

DOI: 10.1093/NAR/17.15.6065

Synthesis and biological evaluation of some phosphate triester derivatives of the anti-viral drug AraA.

Novel phosphate triester derivatives of the anti-viral drug AraA show potential as anti-viral agents due to their resistance to hydrolysis at physiological pH and their ability to inhibit DNA synthesis in mammalian cells.

1989·49citations·Christopher McGuigan et al.·Nucleic acids research

Nucleic acids research

DOI: 10.1038/337615A0

Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1

The crystal structure of HIV-1 protease suggests a mechanism for autoproteolytic release and a role in controlling virus maturation.

1989·816citations·M. Navia et al.·Nature

Nature

DOI: 10.7326/0003-4819-110-3-189

Circulating p24 antigen levels and responses to dideoxycytidine in human immunodeficiency virus (HIV) infections. A phase I and II study.

Dideoxycytidine is a safe and effective treatment for advanced HIV infection, with less toxic regimens warranting clinical assessment.

1989·193citations·T. Merigan et al.·Annals of internal medicine

Annals of internal medicine

DOI: 10.1097/00002030-198902000-00009

Comparison of antigen capture assays against HIV-1 in evaluating antiviral compounds.

Antigen capture ELISAs are sensitive to low levels of HIV-1 antigens, but their characteristics differ in titrating virus antigens for evaluating antiviral compounds.

1989·29citations·D. Kinchington et al.·AIDS

AIDS

DOI: 10.1073/PNAS.83.21.8333

Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

Azidothymidine monophosphate effectively inhibits HIV replication in cells, with its selective interaction with HIV reverse transcriptase indicating its potential as a vaccine.

1986·1232citations·Phillip A. FURMANt et al.·Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America

DOI: 10.1016/S0140-6736(86)92808-4

ADMINISTRATION OF 3'-AZIDO-3'-DEOXYTHYMIDINE, AN INHIBITOR OF HTLV-III/LAV REPLICATION, TO PATIENTS WITH AIDS OR AIDS-RELATED COMPLEX

AZT, an inhibitor of HTLV-III/LAV replication, shows potential in improving immune function and clinical symptoms in AIDS patients without significant side effects.

1986·736citations·R. Yarchoan et al.·The Lancet

The Lancet

Citations

DOI: 10.1039/d2ra00486k

Remdesivir analog as SARS-CoV-2 polymerase inhibitor: virtual screening of a database generated by scaffold replacement

Remdesivir, an antiviral nucleotide analogue, shows potential as a promising SARS-CoV-2 polymerase inhibitor, with HA-130383 and HA-130384 as potential lead compounds.

2022·5citations·Mohamed A. Said et al.·RSC Advances

RSC Advances

DOI: 10.26717/bjstr.2021.38.006195

"Repurposing of Heterocyclic Compounds as Anti- COVID-19 (SARS-Cov-2) Therapeutics: A Review"

Heterocyclic compounds show potential as anti-COVID-19 therapeutics, offering a new class of advanced medicine to combat the pandemic.

2021·1citation·Rakesh Kumar·Biomedical Journal of Scientific & Technical Research

Biomedical Journal of Scientific & Technical Research

DOI: 10.1002/cbdv.202000937

An AZT Analog with Strongly Pairing Ethynylpyridone Nucleobase and Its Antiviral Activity against HSV1

AZW, a strongly binding thymidine analog, shows stronger inhibitory effect than AZT against Herpes simplex virus type 1, suggesting potential as active pharmaceutical ingredients with antiviral activity.

2020·3citations·Jianyang Han et al.·Chemistry & Biodiversity

Chemistry & Biodiversity

DOI: 10.1021/acsmedchemlett.0c00170.s001

A Phosphoramidate Strategy Enables Membrane Permeability of a Non-nucleotide Inhibitor of the Prolyl Isomerase Pin1.

The ProTide approach can enable membrane permeability of non-nucleotide inhibitors of prolyl isomerase Pin1, potentially benefiting other impermeable phosphate-containing inhibitors.

2020·4citations·Daniel M. C. Schwarz et al.·ACS medicinal chemistry letters

ACS medicinal chemistry letters

DOI: 10.1021/acscentsci.0c00489

Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19

Remdesivir, a nucleotide analogue prodrug, has shown potential in inhibiting coronavirus replication, including SARS-CoV-2, and has been approved for emergency use in COVID-19 treatment.

2020·709citations·R. Eastman et al.·ACS Central Science

ACS Central Science