Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase and epidermal growth factor receptor.

doi:10.1016/j.bmc.2010.11.007

Paper

Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase and epidermal growth factor receptor.

Published 2011 · H. Rode, M. Sos, C. Grütter

Bioorganic & medicinal chemistry

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8

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Abstract

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Study Snapshot

7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles show potential as inhibitors of myosin light chain kinase and epidermal growth factor receptor kinase, with their inhibitory effect depending on the nature

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase and epidermal growth factor receptor.

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