Paper
Synthesis and biological evaluation of RON-neoglycosides as tumor cytotoxins.
Published Dec 13, 2011 · J. M. Langenhan, M. Endo, Jeffrey M Engle
Carbohydrate research
Q2 SJR score
24
Citations
1
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
The structure of RON-neoglycoside linkages influences both the potency and selectivity of digitoxin neoglycosides as tumor cytotoxins, with sugar structure being the most significant factor in their synthesis and biological evaluation.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Synthesis and Evaluation of the α-d-/α-l-Rhamnosyl and Amicetosyl Digitoxigenin Oligomers as Antitumor Agents
The -l-rhamnose and -l-amicetose digitoxin analogues show stronger apoptosis inducing activity and cytotoxicity against nonsmall cell human lung cancer cells, with a sugar-chain length dependent cytotoxicity.
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ACS Medicinal Chemistry Letters
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C5'-methyl group in rhamnosyl- and amicetosyl-digitoxigenin analogs induces apoptosis and inhibits tumor growth in non-small cell lung cancer cells, but its anti-tumor activity decreases with increased steric hindrance.
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ACS medicinal chemistry letters
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
Digitaloxin analogues with -l-rhamnose and -l-amicetose sugar moieties show excellent selectivity and activity against human non-small cell lung cancer cells, with at least 5-fold greater apoptosis induction than digitoxin.
2011·61citations·Hua-Yu L Wang et al.·ACS medicinal chemistry letters
ACS medicinal chemistry letters
Assessment of chemoselective neoglycosylation methods using chlorambucil as a model.
Chemoselective glycosylation of chlorambucil can lead to neoglycosides with increased anticancer activity, such as D-threoside 60, which shows broader tumor specificity and increased potency compared to the parent drug.
2010·50citations·Randal D. Goff et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
A Direct Comparison of the Anticancer Activities of Digitoxin MeON-Neoglycosides and O-Glycosides: Oligosaccharide Chain Length-Dependent Induction of Caspase-9-Mediated Apoptosis.
Digitoxin MeON-neoglycosides and O-glycosides show comparable anticancer activity, with both classes inducing caspase-9-mediated apoptosis in non-small cell lung cancer cells.
2010·103citations·A. Iyer et al.·ACS medicinal chemistry letters
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Citations
Borane–Trimethylamine Complex: A Versatile Reagent in Organic Synthesis
Borane-trimethylamine complex (Me3NBH3) is a versatile and cost-effective reagent in organic synthesis, with applications in carbonyl group reduction, carbon-nitrogen double bond reduction, and regioselective cleavage of cyclic acetals.
2024·0citations·Dario Perdicchia·Molecules
Molecules
Development of a multifunctional neoglycoside auxiliary for applications in glycomics research.
The tetrazine-containing neoglycoside auxiliary effectively aids in the isolation and purification of complex carbohydrate mixtures, facilitating future glycomics investigations.
2021·0citations·Thamrongsak Cheewawisuttichai et al.·Organic & biomolecular chemistry
Organic & biomolecular chemistry
Glycorandomization: A promising diversification strategy for the drug development.
Glycorandomization is a promising technology for drug discovery, enhancing solubility, mechanism of action, target recognition, and toxicity of natural products.
2021·15citations·Bharat Goel et al.·European journal of medicinal chemistry
European journal of medicinal chemistry
Conjugation of Oligonucleotides to Peptide Aldehydes via a pH-Responsive N-Methoxyoxazolidine Linker.
A pH-responsive N-methoxyoxazolidine linker allows for the preparation of oligonucleotide-peptide conjugates, with potential for optimization of ligation and cleavage rates.
2020·6citations·A. Aho et al.·Organic letters
Organic letters
Digitoxin
Digitoxin increases intracellular sodium and calcium levels and decreases intracellular potassium levels, leading to cell death and inhibiting cancer cell growth.
2020·0citations·Bezeichnung Des Arzneimittels et al.·Definitions
Definitions